Label-free ratiometric electrochemical detection of the mutated apolipoprotein E gene associated with Alzheimer's disease

A novel ratiometric electrochemical nanosensing platform was developed based on graphene and mesoporous hybrid nanomaterials for detection of the mutated apolipoprotein E gene associated with Alzheimer's disease. The introduction of ratiometric assay could cancel out some systematic errors and significantly improved the sensing performance, such as reproducibility, reliability and accuracy.