4.6 Article

Substantial effect of silk fibroin reinforcement on properties of hydroxyapatite/silk fibroin nanocomposite for bone tissue engineering application

期刊

JOURNAL OF MOLECULAR STRUCTURE
卷 1206, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.molstruc.2020.127739

关键词

Biodegradability; Hydroxyapatite; Silk fibroin; Biomineralization; In-situ co-precipitation method

向作者/读者索取更多资源

Nano-biocomposites that mimics bone's extracellular matrix with hydroxyapatite as an inorganic and silk fibroin as organic phase for three different ratios via a simple in-situ co-precipitation method have been synthesized. The silk fibroin, a biodegradable polymer from cocoons of Bombyx mori silkworm were extracted by employing a chemical-free High-Temperature High-Pressure method as a degumming route. Then followed by the regeneration process which was done by using calcium chloride-formic acid solvent system to replace time-consuming, cost-effective traditional methods. The prepared composites were structurally analyzed using Fourier Transform Infra-Red spectroscopy (FTIR) and X-ray Diffraction (XRD) techniques. The morphology and the elemental composition of the nano-biocomposites were examined using Field Emission Scanning Electron Microscopy (FESEM) and Energy-dispersive X-ray Spectroscopy (EDX). The in-vitro bioactivity of the bio-composites namely, swelling ratio, biodegradation and biomineralization ability is monitored in the presence of Simulated Body Fluid (SBF). Our observation demonstrate that silk fibroin concentration influences the formation of hydroxyapatite. (C) 2020 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据