Solubility modelling and solvent effect on solid-liquid equilibrium of 2,2-bis(hydroxymethyl)butyric acid at different temperatures

In this work, the solid-liquid equilibrium of 2,2-bis(hydroxymethyDbutyric acid (DMBA) was investigated experimentally in various solvents: namely, ethylacetate. butylacetate, methyl isobutyl ketone. cyclopentyl methyl ether, toluene, gamma-butyrolactone and 1,4-dioxane over the temperature range (298.15 to 353.15) K. The experimental solubility data were correlated with the Apelblat equation, Buchowski-Ksiazczak lambda h equation and NRTL model. Results showed that the mole fraction solubility of DMBA increased, as temperature increased. The Apelblat equation and NRTL model indicated a good correlation with the experimental solubility data and can be used to describe the solid-liquid equilibrium. Further, the apparent thermodynamic dissolution functions and thermodynamic functions of mixing were evaluated from the solubility data. (C) 2020 Published by Elsevier B.V.