Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5] arene-modified gold nanoparticles, has been fabricated, which demonstrated good responses to competitive binding and temperature variation. This multifunctional nanosystem combines the excellent characteristics of two kinds of nanoparticles and utilizes a supramolecular host-guest approach for on-demand cargo release.