期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 49, 页码 7633-7652出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02202b
关键词
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资金
- National Natural Science Foundation of China [51403075, 51303174, 51390484, 51473165, 51321062]
- Scientific Development Program of Jilin Province [20140520050JH, 20140309005GX]
- Department of Housing and Urban-Rural Development of Jilin Province [2014-K1-020]
Glucose-sensitive drug delivery systems, which can continuously and automatically regulate drug release based on the concentration of glucose, have attracted much interest in recent years. Self-regulated drug delivery platforms have potential application in diabetes treatment to reduce the intervention and improve the quality of life for patients. At present, there are three types of glucose-sensitive drug delivery systems based on glucose oxidase (GOD), concanavalin A (Con A), and phenylboronic acid (PBA) respectively. This review covers the recent advances in GOD-, Con A-, or PBA-mediated glucose-sensitive nanoscale drug delivery systems, and provides their major challenges and opportunities.
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