期刊
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
卷 30, 期 5, 页码 749-752出版社
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.2003.03025
关键词
Inula britannica; inularin; melanogenesis; B16F10 melanoma cells; zebrafish embryos
资金
- National Marine Biodiversity Institute Research Program - Ministry of Oceans and Fisheries (MOF) [2020M00600]
- Korea Institute of Oriental Medicine [KSN2012330]
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the Agricultural Research Center Project - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [710013-03-2-SB120]
In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.
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