期刊
JOURNAL OF MEDICAL VIROLOGY
卷 93, 期 6, 页码 3601-3606出版社
WILEY
DOI: 10.1002/jmv.26054
关键词
HIV-1; IFN-lambda 4; SNP; viral load
类别
资金
- FAPESP [2017/08320-5, 2018/07239-2, 2016/03025-2, 2019/18522-0]
- CNPq [301372/2013-6]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/08320-5, 19/18522-0] Funding Source: FAPESP
While IFN-lambda 4 rs8099917 polymorphisms were not associated with AIDS progression, the wild type genotype (CC) of IFN-lambda 4 rs12979860 was found to be associated with higher mortality in HIV-infected patients, indicating genetic variations in IFN-lambda 4 may impact mortality risk.
Few studies have reported the prognosis of human immunodeficiency virus (HIV)-positive patients followed for a long time in Brazil, particularly those including pre and post-HAART eras. The polymorphisms of interferon (IFN)-lambda 4 have been postulated as possibly associated with the pathogenesis of HIV infection. The aim of this study was to describe the incidence and mortality from a cohort of HIV-positive patients as well as whether IFN-lambda 4 gene polymorphisms (SNP rs8099917 and SNP rs12979860) were associated with HIV/acquired immune deficiency syndrome (AIDS) progression. We followed 402 patients for up to 30 years; 347 of them began follow-up asymptomatic, without any AIDS-defining opportunistic disease and/or a lymphocytes T CD4+ count of 350 cells/mm(3)or lower. We determined the probability of the asymptomatic subjects to remain AIDS-free, and the risk of death for those entering the study already with an AIDS diagnosis, as well as for subjects developing AIDS during follow-up. We compared the prognosis of patients with two different polymorphisms for the genes encoding for IFN-lambda 4, variants rs8099917 and rs12979860. The follow-up time of the 347 asymptomatic-at-entry subjects was 3687 person-years. IFN-lambda 4 rs8099917 polymorphisms were not associated with AIDS progression, but IFN-lambda 4 rs12979860 wild type genotype (CC) was associated with higher mortality compared to CT and TT, with an increased probability of death from AIDS (P = .01). In conclusion, genetic variations in IFN-lambda 4 on rs12979860 polymorphisms in HIV-infected patients may drive mortality risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据