期刊
JOURNAL OF MEDICAL GENETICS
卷 57, 期 11, 页码 725-732出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jmedgenet-2019-106763
关键词
genetic epidemiology; getting research into practice; prevention; genome-wide; clinical genetics
The use of genomic information to better understand and prevent common complex diseases has been an ongoing goal of genetic research. Over the past few years, research in this area has proliferated with several proposed methods of generating polygenic scores. This has been driven by the availability of larger data sets, primarily from genome-wide association studies and concomitant developments in statistical methodologies. Here we provide an overview of the methodological aspects of polygenic model construction. In addition, we consider the state of the field and implications for potential applications of polygenic scores for risk estimation within healthcare.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据