期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 89, 页码 13086-13089出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc06451e
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资金
- School of Chemistry TCD
- Science Foundation Ireland (SFI) [PI 2013 13/IA/1865]
Glycosylated 4-amino-1,8-naphthalimide derivatives possess a native glycosidic linkage that can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging or therapeutic agent. In vitro studies using a variety of cancer cell lines demonstrated that the naphthalimides only get taken up into cells upon enzymatic cleavage from the glycan unit; a mechanism that offers a novel approach for the targeted delivery of probes/drugs.
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