Highly selective Markovnikov hydroboration of alkyl-substituted terminal alkenes with a phosphine-copper(I) catalyst

A new method has been developed for the Markovnikov hydroboration of alkyl-substituted terminal alkenes. Notably, the use of a bulky bisphosphine-copper(I) catalyst system resulted in high regioselectivity to afford secondary alkylboronates from the corresponding terminal alkenes (branch/linear = 92 : 8-97: 3). This method also exhibited good functional group compatibility.