期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 67, 页码 10237-10240出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc05490k
关键词
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资金
- Major National Scientific Research Projects [2013CB910200]
- National Natural Science Foundation of China [21473095, 21273121]
- Australian Research Council [DP150100383]
Determining the three-dimensional structure of a protein in living cells remains particularly challenging. We demonstrated that the integration of site-specific tagging proteins and GPS-Rosetta calculations provides a fast and effective way of determining the structures of proteins in living cells, and in principle the interactions and dynamics of protein-ligand complexes.
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