期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 87, 页码 12897-12900出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc07574f
关键词
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资金
- National Natural Science Foundation of China [21135002, 21635005, 21675082, 21322506]
- National Basic Research Program [2014CB744501]
A lysosome-accessing nanoprobe is designed for recognition of lysosomal neuraminidases (Lyso-Neus), which can cleave the 4-methyl-umbelliferone moieties of the substrate from the nanoprobe, and lead to the escape of the moieties from acidic lysosomes into the neutral cytosol assisted by cationic poly(ethyleneimine) to light up the pH-responsive fluorescence for visual detection and dynamic tracking of Lyso-Neu activity in living cells.
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