4.7 Article

Enhanced copper-mediated F-18-fluorination of aryl boronic esters provides eight radiotracers for PET applications

期刊

CHEMICAL COMMUNICATIONS
卷 52, 期 54, 页码 8361-8364

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc03295h

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资金

  1. UCB
  2. Swiss National Science Foundation
  3. CRUK
  4. BBSRC
  5. MRC
  6. Advion
  7. EPSRC
  8. Royal Society
  9. Biotechnology and Biological Sciences Research Council [1379809] Funding Source: researchfish
  10. Cancer Research UK [16466] Funding Source: researchfish
  11. Engineering and Physical Sciences Research Council [EP/L025604/1] Funding Source: researchfish
  12. Medical Research Council [1580544] Funding Source: researchfish
  13. EPSRC [EP/L025604/1] Funding Source: UKRI

向作者/读者索取更多资源

[F-18]FMTEB, [F-18]FPEB, [F-18]flumazenil, [F-18]DAA1106, [F-18]MFBG, [F-18]FDOPA, [F-18]FMT and [F-18]FDA are prepared from the corresponding arylboronic esters and [F-18]KF/K-222 in the presence of Cu(OTf)(2)py(4). The method was successfully applied using three radiosynthetic platforms, and up to 26 GBq of non-carrier added starting activity of F-18-fluoride.

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