期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 100, 页码 14434-14437出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc09172e
关键词
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资金
- EPSRC Centre for Doctoral Training in Synthesis for Biology and Medicine [EP/L015838/1]
- Engineering and Physical Sciences Research Council [1802223] Funding Source: researchfish
A three component reductive coupling reaction of a (hetero)aromatic amine, a (hetero) aromatic aldehyde and an electron deficient olefin catalysed by eosin Upsilon under green LED light irradiation, for the direct generation of gamma-amino acid derivatives, is described. This new umpolung synthesis of amines, which exploits the high nucleophilicity of a putative a-amino radical intermediate, generated via single electron reduction of the in situ generated imine from the Hantzsch ester terminal reductant, is efficient, operationally simple, broad in scope and offers a complementary strategy to existing synthetic approaches.
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