Advances on the role of the deleted in breast cancer (DBC1) in cancer and autoimmune diseases

DBC1 (deleted in breast cancer 1) is a human nuclear protein that modulates the activities of various proteins. Most of the research on DBC1 has focused on metabolism and epigenetics because it is a crucial endogenic inhibitor of deacetylase Sirtuin1 (SIRT1). In this review, we have discussed and summarized the new advances in DBC1 research, mostly focusing on its structure, regulatory function, and significance in cancer and autoimmune diseases.

Automated summary

DBC1 is a human nuclear protein that plays a crucial role in modulating the activities of various proteins, with a focus on metabolism and epigenetics. It is known for its inhibition of SIRT1 and its significance in cancer and autoimmune diseases. Research has made new advances in understanding the structure, regulatory function, and importance of DBC1.