期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 30, 页码 5269-5272出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc01554a
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资金
- Soochow University
- National Natural Science Foundation of China [21402134]
- Natural Science Foundation of Jiangsu Province [BK20140306]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
An efficient synthesis of highly functionalized gamma-hydroxybutenolides through BF3-catalyzed annulation of keto acids with alkynes is described. Many advantages such as the use of routine reagents, easy operation, and a 100% atom efficiency are demonstrated in the method. The reaction can be readily scaled up to gram quantities, offering good practicality.
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