4.7 Article

How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

期刊

CHEMICAL COMMUNICATIONS
卷 52, 期 34, 页码 5832-5835

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00898d

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资金

  1. CAPES-Brazil/PVE-Program
  2. CAPES-Brazil/PDSE scholarship [7537/13-1]
  3. National Institute of General Medical Sciences of the National Institutes of Health (NIH) [R01GM107146]

向作者/读者索取更多资源

Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pH(max) above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.

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