4.7 Article

Vertical Transmission of Gut Microbiome and Antimicrobial Resistance Genes in Infants Exposed to Antibiotics at Birth

期刊

JOURNAL OF INFECTIOUS DISEASES
卷 224, 期 7, 页码 1236-1246

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa155

关键词

microbiome; gut microbiome; microbiome transmission; antimicrobial resistance genes; AMR; antibiotics; infant microbiome

资金

  1. Academy of Finland
  2. Pediatric Research Foundation, Finland
  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services [U19AI110819]

向作者/读者索取更多资源

The study found that perinatal antibiotics significantly disrupted vertical transmission of maternal microbes to infants, changing the source of gut colonization towards horizontal transfer from the environment to the infants.
Vertical transmission of maternal microbes is a major route for establishing the gut microbiome in newborns. The impact of perinatal antibiotics on vertical transmission of microbes and antimicrobial resistance is not well understood. Using a metagenomic approach, we analyzed the fecal samples from mothers and vaginally delivered infants from a control group (10 pairs) and a treatment group (10 pairs) receiving perinatal antibiotics. Antibiotic-usage had a significant impact on the main source of inoculum in the gut microbiome of newborns. The control group had significantly more species transmitted from mothers to infants (P = .03) than the antibiotic-treated group. Approximately 72% of the gut microbial population of infants at 3-7 days after birth in the control group was transmitted from their mothers, versus only 25% in the antibiotic-treated group. In conclusion, perinatal antibiotics markedly disturbed vertical transmission and changed the source of gut colonization towards horizontal transfer from the environment to the infants.

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