期刊
JOURNAL OF INFECTIOUS DISEASES
卷 222, 期 6, 页码 1046-1050出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa187
关键词
Mycobacterium kansasii; granuloma; infection; cords; zebrafish; macrophage
资金
- Labex EpiGenMed through the Investissements d'Avenir program [ANR-10-LABX-12-01]
Mycobacterium kansasii is a slow-growing nontuberculous mycobacteria responsible for coinfections particularly in patients with human immunodeficiency virus. To date, our knowledge of M. kansasii infection has been hampered owing to the lack of an effective animal model to study pathogenesis. In the current study, we showed that the zebrafish embryo is permissive to M. kansasii infection, resulting in chronic infection and formation of granulomas. On macrophage depletion, we identified M. kansasii forms extracellular cords, resulting in acute infection and rapid larval death. These findings highlight the feasibility of zebrafish for studying M. kansasii pathogenesis and for the first time identify extracellular cords in this species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据