期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 88, 页码 13043-13046出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc07153h
关键词
-
资金
- National Natural Science Foundation of China [21505129]
- Natural Science Foundation of Jilin Province [20160101296JC]
We report a new nucleic acid sensing strategy through an intelligent design of spatial organization based reciprocal switching of catalytic hairpin assembly (CHA). The so-called SORS-CHA not only turns a well-designed CHA circuit into a relatively universal detector for any targeting sequence, but also guarantees a much enhanced signal resolution and a believability to minimize the misreading induced by unexpected signal drifts. Withmore trustworthy results, but a simpler sequence design, nucleic acid circuits could become competitive in real-world applications.
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