期刊
JOURNAL OF INFECTIOUS DISEASES
卷 222, 期 2, 页码 198-202出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa252
关键词
SARS-CoV2; lymphocyte subsets; diagnosis; prognosis
资金
- Applied Research Training Program of Jiangxi Province [20181BBG78057]
- Science and Technology Plan Project of Jiangxi Provincial Health Planning Commission [20165168]
- Science and Technology Research Project of the Jiangxi Provincial Department of Education [GJJ150127]
This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3(+) T cells, CD4(+) T cells, CD8(+) T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4(+) T cells but a severe decrease in CD8(+) T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8(+ )T and CD4(+)T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
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