期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 82, 页码 12155-12158出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc06024b
关键词
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资金
- Welch Foundation [I-1855]
- Cancer Prevention and Research Institute of Texas (CPRIT) [R1212, RP140110]
- Mary Kay Foundation [049-15]
Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.
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