期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 85, 页码 12657-12660出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc05110c
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资金
- DST
- UGC
- CSIR
- ICMR
- DST, India [SR/S0/BB/0102/2012]
An antimitotic cell penetrating octapeptide containing single Arg amino acid is discovered, which strongly binds with the exchangeable GTP/GDP binding site of tubulin, inhibits tubulin polymerization, reduces kinesin driven microtubule motility, activates apoptotic and mitotic check point proteins, induces apoptotic death and significantly inhibits the multicellular tumor spheroid growth of HeLa cells.
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