Transfer and amplification of chirality in Phe-based C3-symmetric non-ionic amphiphiles

The synthesis of amphiphiles 1 and 2 endowed with three L- or D-Phe units is reported. The chiral features provided by the Phe fragment are transferred to the supramolecular level to yield enantiomerically enriched helices. Additionally, we report herein the first example of amplification of chirality demonstrated by MR performed with supramolecular polymers showing very low degree of cooperativity.