期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 42, 页码 6930-6933出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02062c
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We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA sequence, hybridization and furan-oxidation based crosslinking to DNA is investigated. The structure of the crosslinked products is characterized and preliminary investigations concerning the application of these systems to double stranded DNA are shown.
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