Toxicity of different types of quantum dots to mammalian cells in vitro: An update review

Currently, there are a great quantity type of quantum dots (QDs) that has been developed by researchers. Depending on the core material, they can be roughly divided into cadmium, silver, indium, carbon and silicon QDs. And studies on the toxicity of QDs are also increasing rapidly, but in vivo tests in model animals fail to reach a consistent conclusion. Therefore, we review the literatures dealing with the cytotoxicity of QDs in mammalian cells in vitro. After a short summary of the application characteristics of five types of QDs, the fate of QDs in cells will be discussed, ranging from the uptake, transportation, sublocation and excretion. A substantial part of the review will be focused on in vitro toxicity, in which the type of QDs is combined with their adverse effect and toxic mechanism. Because of their different luminescent properties, different subcellular fate, and different degree of cytotoxicity, we provide an overview on the balance of optical stability and biocompatibility of QDs and give a short outlook on future direction of cytotoxicology of QDs.