Two-photon sensitized hollow Gd2O3:Eu3+ nanocomposites for real-time dual-mode imaging and monitoring of anticancer drug release

New two-photon sensitized multifunctional nanocomposites were designed for dual-mode imaging and real-time drug release monitoring by photoluminescence (PL) and magnetic resonance imaging (MRI). By drug loading based on coordination effect, PL signals of Eu3+ and MRI signals of Gd3+ can be stabilized and enhanced, respectively, which then display excellent linear decreases on drug release.