期刊
JOURNAL OF DRUG TARGETING
卷 28, 期 7-8, 页码 789-801出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1061186X.2020.1744156
关键词
Sugar; liposome; target efficiency; C6 glioma cells; PEG600-DSPE
资金
- Fundamental Research Funds for the Provincial Universities of Heilongjiang province [2017JCZX08]
- Scientific Research Fund of Harbin Medical University-Daqing [DQXN201603]
- Heilongjiang Provincial Natural Science Foundation [ZD2016013]
- National Natural Science Foundation of China [21506044]
- Fundamental Research Funds for the Provincial Universities of Heilongjiang province in 2018
Ligands are an important part of targeted drug delivery systems. Optimised lignads not only improve the target efficiency, but also enhance therapeutical effect of drugs. In our research, five sugar molecules (Mannose, Galactose, Glucose, Malt disaccharide, and Maltotriose) conjugated PEG(600)-DSPE were synthesised, of which polysaccharides were first discovered by us as sugar ligands to modify liposomes, which interacts with over expressive GLUT on cancer cells. DiO was encapsulated as fluorescent probe to evaluate their cellular uptake abilities of targeting C6 glioma cells, and the distribution in different visceral organs of rats. The results demonstrated that Malt disaccharide and Glucose-PEG(600)-DSPE had the strong efficiency of cellular uptake by C6 glioma cells. The distribution and accumulation of liposomes showed that different sugars modified liposomes could target different visceral organs in rats. It has provided a novel idea for ligand selectivity and optimisation of nanocarriers for tumour targeted therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据