期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 33, 期 1, 页码 54-61出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2020.1747592
关键词
Ixekizumab; indirect comparison; psoriasis; interleukin-23 inhibitors
类别
资金
- Eli Lilly and Company
This study compared the speed of onset and level of skin improvement between the IL-17A antagonist ixekizumab and the IL-23 p19 inhibitors guselkumab, tildrakizumab, and risankizumab in patients with moderate-to-severe plaque psoriasis. The results showed that ixekizumab had a faster onset of effect and greater clinical benefits than the IL-23 p19 inhibitors up to week 12.
Background: It is challenging to select the most appropriate biologic treatment for patients with moderate-to-severe plaque psoriasis. Objective: To compare speed of onset and level of skin improvement between the interleukin (IL)-17A antagonist ixekizumab and the IL-23 p19 inhibitors guselkumab, tildrakizumab, and risankizumab in patients with moderate-to-severe plaque psoriasis. Methods: Using data from controlled clinical trials, both adjusted indirect comparisons (AICs) and matching adjusted indirect comparisons (MAICs) were performed to determine the risk difference (RD) between ixekizumab and each IL-23 p19 inhibitor for the proportion of patients with >= 75%/90%/100% improvement compared with baseline in Psoriasis Area and Severity Index (PASI 75/90/100) up to week 12. Placebo, etanercept, or ustekinumab were used as the comparator bridge. Results: In all (M)AICs, RDs generally significantly favored ixekizumab over guselkumab (placebo bridge), tildrakizumab (placebo or etanercept bridge), and risankizumab (placebo or ustekinumab bridge) from the earliest assessment time (>= week 2) to week 12 when considering PASI 75/90/100 responses. Conclusion: Ixekizumab provides a faster onset of effect and earlier clinical benefits than guselkumab, tildrakizumab, or risankizumab in patients with moderate-to-severe psoriasis, as reflected by higher levels of skin improvement than with these IL-23 p19 inhibitors up to week 12.
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