期刊
JOURNAL OF COORDINATION CHEMISTRY
卷 73, 期 4, 页码 593-608出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2020.1739273
关键词
Silver nanoparticles; zinc porphyrins; singlet oxygen quantum yield; photodynamic antimicrobial chemotherapy
Asymmetric mono-carboxy-porphyrins, (5-(4-carboxyphenyl)-10,15,20-tris(pentafluorophenyl)porphyrinato zinc(II) (1), 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrinato zinc(II) (2) and 5-(4-carboxyphenyl)-10,15,20-tris(2-thienyl)porphyrinato zinc(II) (3), were linked to Ag nanoparticles (AgNPs) through amide bonds and self-assembly (the latter only for 3). The porphyrins and conjugates were used for photodynamic antimicrobial chemotherapy (PACT) against Staphylococcus aureus. PACT uses singlet oxygen for antimicrobial activity. Complex 3 and its conjugates had higher singlet oxygen quantum yields and higher log reduction when compared with the rest of the porphyrins and corresponding conjugates. These high log reductions for 3 and its conjugate were attributed to the presence of sulfur groups whereby there was more interaction with the bacterial membrane.
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