期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 35, 页码 6005-6008出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00590j
关键词
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资金
- China National Natural Science Foundation [21402120]
- Shanghai Sciences and Technologies Development Fund [13ZR1458700]
- Shanghai Municipal Education Commission [14YZ074, 13CG48]
Construction of a site-isolated heterogeneous catalyst to realize the compatibility of bimetallic complexes for a feasible tandem reaction is a significant challenge in heterogeneous asymmetric catalysis. Herein, taking advantage of yolk-shell-structured mesoporous silica, we assemble an active site-isolated bifunctional catalyst through assembly of organopalladium-functionality into silicate channels as an outer shell and chiral organoruthenium-functionality onto silicate yolk as an inner core, realizing the one-pot enantio-selective tandem reaction from Pd-catalyzed Sonogashira coupling to Ru-catalyzed asymmetric transfer hydrogenation. As presented in this study, this tandem Sonogashira coupling-asymmetric transfer hydrogenation of haloacetophenones and arylacetylenes affords various chiral conjugated alkynols with high yields and up to 99% enantioselectivity. Moreover, a catalyst can also be recovered easily and recycled repeatedly, making it an interesting feature in a practical organic transformation.
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