期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 566, 期 -, 页码 284-295出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2020.01.098
关键词
Au nanoparticle; Se nanoparticle; Chain-oligomer; Laser ablation; Green synthesis; Photothermal therapy; Directional assembly; Bipolar interaction; Long-term stability; High photothermal transduction efficiency
资金
- Instrument Developing Project of the Chinese Academy of Sciences [YZ201627]
- National Natural Science Foundation of China (NSFC) [51571186, 11674321, 51801205]
For the potential use of Au nanoparticles (NPs) in photothermal therapy, it is important and effective to achieve the uniaxial assembly of Au NPs to allow enhanced absorption in the near infrared (NIR) region. Herein, we first presented the construction of amorphous selenium encapsulated gold (Se@Au) chainoligomers by successive laser ablation of Au and Se targets in sodium chloride solution without other toxic precursors, stabilizers, or templating molecules. Se@Au chain-oligomers showed evidently enhanced NIR absorption and excellent photothermal transduction efficiency (i), which was higher than 47% at 808 nm. After being stored for I year, the Se@Au colloids still exhibited outstanding photothermal performance. The cytotoxicity assay demonstrated that there is negligible toxicity of Se@Au chain-oligomers in cells, but cell viability declined to only 1% in phototherapeutic experiments that were implemented in vitro. In intracellular Reactive Oxygen Species (ROS) generation measurements, Se@Au chain-oligomers could trigger a 35.9% increment of ROS upon laser irradiation. The possible synergetic effects between the anticancer function of Se and photothermal behaviors of Se@Au intended to increase ROS level in cells. Therefore, such designed Se@Au chain-oligomers of high stability exhibit promising potential for their use as in vivo photothermal therapeutic agents. (C) 2020 Elsevier Inc. All rights reserved.
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