期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 98, 页码 14101-14104出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc08254h
关键词
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资金
- 973 program [2014CB845604, 2015CB856301]
- National Science Foundation of China [21231007, 21172274, 21572282, 21401217]
- Ministry of Education of China [IRT1298]
- Guangdong government [207999, 2015A030306023]
- China's Post-doctoral Science Fund [2014M562208]
- Fundamental Research Funds for the Central Universities
Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence.
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