期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 130, 期 5, 页码 2202-2205出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI137647
关键词
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资金
- Rudolf J. Anderson Fellowship
- NIH [R01 AI141009, R61 DA047037, R01 AI147868, UM1 AI126620]
- Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH) [P50 AI150464]
- Gilead HIV Research Scholar Grant
- American Foundation for AIDS Research (amfAR)
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-alpha), lymphopenia (in CD4(+) and CD8(+) T cells), and decreased IFN-gamma expression in CD4(+) T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.
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