相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain
James R. Burke et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Three Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis
Atul Deodhar et al.
ARTHRITIS & RHEUMATOLOGY (2019)
Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs
Massimo Gadina et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2018)
Psoriatic arthritis 2 Clinical management of psoriatic arthritis
Filip Van den Bosch et al.
LANCET (2018)
Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study
Atul Deodhar et al.
LANCET (2018)
From genome-wide associations to candidate causal variants by statistical fine-mapping
Daniel J. Schaid et al.
NATURE REVIEWS GENETICS (2018)
IL-17 in the immunopathogenesis of spondyloarthritis
Leonie S. Taams et al.
NATURE REVIEWS RHEUMATOLOGY (2018)
Enthesitis: A hallmark of psoriatic arthritis
Gurjit S. Kaeley et al.
SEMINARS IN ARTHRITIS AND RHEUMATISM (2018)
The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+and CD8+memory T-cells
C. Enerback et al.
SCIENTIFIC REPORTS (2018)
γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis
Laura Bouchareychas et al.
SCIENTIFIC REPORTS (2018)
Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study
Dominique Baeten et al.
ANNALS OF THE RHEUMATIC DISEASES (2018)
Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis
Kim Papp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases
Ariane Hammitzsch et al.
SCIENTIFIC REPORTS (2018)
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis
Isabelle Cambre et al.
NATURE COMMUNICATIONS (2018)
Secukinumab Versus Adalimumab for Psoriatic Arthritis: Comparative Effectiveness up to 48 Weeks Using a Matching-Adjusted Indirect Comparison
Peter Nash et al.
RHEUMATOLOGY AND THERAPY (2018)
Secukinumab efficacy in anti-TNF-naive and anti-TNF-experienced subjects with active ankylosing spondylitis: results from the MEASURE 2 Study
Joachim Sieper et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study
Juergen Braun et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis
Katelijne De Wilde et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
Fine-mapping inflammatory bowel disease loci to single-variant resolution
Hailiang Huang et al.
NATURE (2017)
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
Daniella M. Schwartz et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Enthesitis: from pathophysiology to treatment
Georg Schett et al.
NATURE REVIEWS RHEUMATOLOGY (2017)
Pathogenesis of ankylosing spondylitis - recent advances and future directions
Vidya Ranganathan et al.
NATURE REVIEWS RHEUMATOLOGY (2017)
How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches
Kliment A. Verba et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
Group 3 Innate Lymphoid Cells in Human Enthesis
Richard J. Cuthbert et al.
ARTHRITIS & RHEUMATOLOGY (2017)
Progress of genome-wide association studies of ankylosing spondylitis
Zhixiu Li et al.
CLINICAL & TRANSLATIONAL IMMUNOLOGY (2017)
Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study
Desiree van der Heijde et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
IL-17+ γδ T cells as kick-starters of inflammation
Pedro H. Papotto et al.
NATURE IMMUNOLOGY (2017)
Tyrosine kinase 2 is not limiting human antiviral type III interferon responses
Sebastian Fuchs et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2016)
Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases
Doreen M. Floss et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Lalit K. Beura et al.
NATURE (2016)
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
David Ellinghaus et al.
NATURE GENETICS (2016)
CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis
Danay Cibrian et al.
NATURE IMMUNOLOGY (2016)
Ankylosing Spondylitis and Axial Spondyloarthritis
Joel D. Taurog et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Calliope A. Dendrou et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Sexual Dimorphism in the Th17 Signature of Ankylosing Spondylitis
Eric Gracey et al.
ARTHRITIS & RHEUMATOLOGY (2016)
Interleukin-23-Dependent/T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice
Annika Reinhardt et al.
ARTHRITIS & RHEUMATOLOGY (2016)
The 3 major types of innate and adaptive cell-mediated effector immunity
Francesco Annunziato et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
Alexandra Y. Kreins et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis
Eva Hainzl et al.
JOURNAL OF IMMUNOLOGY (2015)
TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits
Dorothee Diogo et al.
PLOS ONE (2015)
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
John Bowes et al.
NATURE COMMUNICATIONS (2015)
Genetic and epigenetic fine mapping of causal autoimmune disease variants
Kyle Kai-How Farh et al.
NATURE (2015)
Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)
Denis Poddubnyy et al.
ANNALS OF THE RHEUMATIC DISEASES (2014)
Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation
Eric Keil et al.
BLOOD (2014)
Inhibition of TYK2 and JAK1 Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis by Inhibiting IL-22 and the IL-23/IL-17 Axis
Melissa G. Works et al.
JOURNAL OF IMMUNOLOGY (2014)
Early infant diagnosis of HIV and fast initiation of anti-retroviral therapy in a rural African setting: how well are we doing?
Sara-Jane Smith et al.
PAEDIATRICS AND INTERNATIONAL CHILD HEALTH (2014)
Interleukin-23 Mediates the Intestinal Response to Microbial β-1,3-Glucan and the Development of Spondyloarthritis Pathology in SKG Mice
Helen Benham et al.
ARTHRITIS & RHEUMATOLOGY (2014)
Suppression of inflammation and effects on new bone formation in ankylosing spondylitis: evidence for a window of opportunity in disease modification
Walter P. Maksymowych et al.
ANNALS OF THE RHEUMATIC DISEASES (2013)
Phosphodiesterase 4-targeted treatments for autoimmune diseases
Neal Kumar et al.
BMC MEDICINE (2013)
Two Rare Disease-Associated Tyk2 Variants Are Catalytically Impaired but Signaling Competent
Zhi Li et al.
JOURNAL OF IMMUNOLOGY (2013)
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
Adrian Cortes et al.
NATURE GENETICS (2013)
Enrichment of Circulating Interleukin-17-Secreting Interleukin-23 Receptor-Positive γ/δ T Cells in Patients with Active Ankylosing Spondylitis
Tony J. Kenna et al.
ARTHRITIS AND RHEUMATISM (2012)
β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice
Merja Ruutu et al.
ARTHRITIS AND RHEUMATISM (2012)
Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22
Hartmann Raifer et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells
Jonathan P. Sherlock et al.
NATURE MEDICINE (2012)
TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo
Michaela Prchal-Murphy et al.
PLOS ONE (2012)
Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
Masayuki Ishizaki et al.
INTERNATIONAL IMMUNOLOGY (2011)
Involvement of Tyrosine Kinase-2 in Both the IL-12/Th1 and IL-23/Th17 Axes In Vivo
Masayuki Ishizaki et al.
JOURNAL OF IMMUNOLOGY (2011)
IL-23 Is Critical for Induction of Arthritis, Osteoclast Formation, and Maintenance of Bone Mass
Iannis E. Adamopoulos et al.
JOURNAL OF IMMUNOLOGY (2011)
The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells
Chrystal M. Paulos et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Frequency and Phenotype of Peripheral Blood Th17 Cells in Ankylosing Spondylitis and Rheumatoid Arthritis
Hui Shen et al.
ARTHRITIS AND RHEUMATISM (2009)
Tyrosine Kinase 2 Plays Critical Roles in the Pathogenic CD4 T Cell Responses for the Development of Experimental Autoimmune Encephalomyelitis
Akiko Oyamada et al.
JOURNAL OF IMMUNOLOGY (2009)
IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage
Gretta L. Stritesky et al.
JOURNAL OF IMMUNOLOGY (2008)
Classification criteria for psoriatic arthritis - Development of new criteria from a large international study
William Taylor et al.
ARTHRITIS AND RHEUMATISM (2006)
STAT3 and NF-κB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
Mi-La Cho et al.
JOURNAL OF IMMUNOLOGY (2006)
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappa B-dependent pathway in patients with rheumatoid arthritis
KW Kim et al.
ARTHRITIS RESEARCH & THERAPY (2005)
Quality of life and work in patients with rheumatoid arthritis and ankylosing spondylitis of working age
AMJ Chorus et al.
ANNALS OF THE RHEUMATIC DISEASES (2003)
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
N Sakaguchi et al.
NATURE (2003)