期刊
JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 55, 期 3, 页码 233-238出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0000000000001357
关键词
polaprezinc; endoscopic submucosal dissection; ulcer
资金
- SK Chemicals
This study compared the efficacy of polaprezinc plus pantoprazole treatment with rebamipide plus pantoprazole treatment for ESD-induced ulcer healing, finding that the former was noninferior to the latter in terms of ulcer healing rate at 4 weeks post-ESD. Additionally, a short procedure time was identified as an independent predictive factor for a high ulcer healing rate.
Goals: We assessed the efficacy of polaprezinc plus proton pump inhibitor (PPI) treatment for endoscopic submucosal dissection (ESD)-induced ulcer healing compared with rebamipide plus PPI treatment. Background: ESD has been widely used as a local treatment option that cures gastric neoplasms. However, it causes large and deep artificial ulcers, and there are no guidelines with regard to the optimal treatment durations and drug regimens for ESD-induced ulcers. Polaprezinc is effective for promoting ulcer healing and helps enhance the quality of ulcer healing. Study: Two hundred ten patients with ESD-induced ulcers were randomly allocated to treatment with polaprezinc (150 mg/d) plus pantoprazole (40 mg/d) or treatment with rebamipide (300 mg/d) plus pantoprazole (40 mg/d). We evaluated the ulcer healing rate and condition of the ulcer at 4 weeks after dissection. The chi(2) or Fisher exact test and the Student t test were used. Results: The ulcer healing rates at 4 weeks after dissection in the polaprezinc plus pantoprazole treatment group were not inferior compared with those in the rebamipide plus pantoprazole treatment group, both in the intention-to-treat analysis (90.3% and 91.4%, respectively, P=0.523) and per-protocol analysis (89.9% and 91.1%, respectively, P=0.531). The short procedure time was an independent predictive factor for a high ulcer healing rate (odds ratio: 0.975; 95% confidence interval: 0.958-0.993; P=0.006). Conclusion: The polaprezinc plus PPI treatment showed noninferiority to rebamipide plus PPI treatment in the ulcer healing rate at 4 weeks after ESD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据