Solubility Determination and Thermodynamic Modeling of Edaravone in Different Solvent Systems and the Solvent Effect in Pure Solvents

The solubility data of edaravone in fourteen neat solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, n-pentanol, acetone, acetonitrile, dichloromethane, ethyl acetate, and 1,4-dioxane) and three binary solvent mixtures (methanol + water, ethanol + water, and isopropanol + water) were determined by the gravimetric method from 283.15 to 323.15 K. The co-solvency phenomenon was found in the mixed solvents of (ethanol + water) and (isopropanol + water). The solute-solvent and solvent-solvent interactions were analyzed by the KAT-LSER model. In addition, the solubility data were correlated by the modified Apelblat model, Jouyban-Acree model, and Apelblat-Jouyban-Acree model. To choose the best model for correlating the edaravone solubility, the Akaike information criterion values and Akaike weights were calculated for each thermodynamic model.