期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 41, 期 3, 页码 546-560出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X20913123
关键词
Capillary shunting; oxygen exchange efficiency; sickle cell anemia; silent cerebral infarcts; white matter hyperintensities
资金
- National Institutes of Health [NIH/NINDS] [5R01NS078828]
- National Institutes of Health [NIH/NCATS] [UL1 TR000445]
- American Heart Association [14CSA20380466, 19CDA34790002]
This study confirmed that the venous hyperintense signal in ASL images of SCA patients may be related to disturbances in oxygen exchange efficiency and small vessel pathology.
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) utilizes arterial blood water as an endogenous contrast agent to provide a quantitative measure of cerebral blood flow (CBF). Recently, hyperintense signal within dural venous sinuses in ASL images of sickle cell anemia (SCA) patients has been shown to be consistent with elevated flow velocities and may indicate capillary shunting and reduced oxygen extraction. Here, we performed oxygen extraction fraction (OEF) and CBF measurements in adults (cumulative n = 114) with (n = 69) and without (n = 45) SCA to test the hypothesis that hyperintense venous ASL signal is associated with reduced OEF. Higher categorical scores of shunting on ASL MRI were associated with lower OEF in participants with silent cerebral infarcts or white matter hyperintensities (p = 0.003), but not in those without lesions (p = 0.551). These findings indicate that venous hyperintense signal in ASL images in SCA patients may represent a marker of capillary-level disturbances in oxygen exchange efficiency and small vessel pathology.
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