期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 64, 期 10, 页码 1519-1522出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c16-00426
关键词
10-demethylated steroid; soft coral; Nephthea erecta; cytotoxicity
资金
- National Museum of Marine Biology Aquarium
- Ministry of Science and Technology (MOST), Taiwan [103-2320-B-291-001-MY3]
A new 10-demethylated steroid, nephtheasteroid A (1), a new 19-oxygenated steroid, nephtheasteroid B (2) as well as five known steroids 3-7 were isolated from the organic extract of a Taiwanese soft coral Neplztlzea erecta. The structure was determined by means of IR, MS, and NMR techniques. Among these metabolites, 1 is rarely found in steroids possessing a 19-norergostane skeleton. In vitro cytotoxicity study using 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that compounds 3 and 4 exhibited cytotoxicity against human chronic myelogenous leukemia (K562), human acute lymphoblastic leukemia (Molt-4), human T lymphoblastoid (Sup-T1), and human leukemic monocyte lymphoma (U937), with IC50 of 6.5-14.0 mu m.
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