期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 64, 期 12, 页码 1707-1712出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c16-00553
关键词
Antidesma hainanensis; lignan; megastigmane; microglia; neuro-inflammation
资金
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2013.05]
Two new lignans (7S,7'R,8S,8'R)-3,3'-dimethoxy-7,7'-epoxylignan-4,4',9-triol 4-O-beta-D-glucopyranoside (1) and 9-O-formylaviculin (2) together with other thirteen known secondary metabolites were isolated from the leaves of Antidesma hainanensis. Their chemical structures were determined using NMR, electrospray ionization (ESI)-MS, circular dichroism (CD) spectroscopic methods, and as well as by comparison with those reported in the literature. Neuro-inflammatory activity of isolated compounds was evaluated by their inhibition on nitric oxide (NO) production in activated BV2 microglial cells. At concentration of 40 mu M, compounds 1-3, 5, 7, 8, 9, 14, and 15 exhibited inhibitory effects over 50%, suggesting that they could be potential candidate drugs for the cure of neuro-inflammation. In addition, compounds 1, 8, 14, and 15 significantly inhibited 16.23, 27.76, 21.23, and 29.44% NO production at diluted concentration as low as 2.5 mu M.
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