期刊
JOURNAL OF CELL BIOLOGY
卷 219, 期 5, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202001161
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资金
- National Institutes of Health [R35GM131715, R01GM080616]
- China Scholarship Council
A single particle cryo-EM reconstruction of an similar to 160-kD N-terminal fragment of the lipid transport protein VPS13 reveals an similar to 160-angstrom long channel lined with hydrophobic residues suitable for solubilizing multiple lipid fatty acid moieties. The structure suggests that VPS13 and related proteins, like the autophagy protein ATG2, can act as bridges between organelle membranes to allow bulk lipid flow between organelles.
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