期刊
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
卷 39, 期 10, 页码 3780-3786出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2020.1767211
关键词
Coronavirus; COVID-19; SARS; MERS; SARS-CoV-2; ACE2; lung; heart
资金
- Qatar National Research Fund (QNRF) under Qatar Foundation [NPRP10-120-170-211]
- GCC Collaborative Research Program from Qatar University [GCC-2017-005]
Researchers have reported useful information about SARS-CoV-2 leading to COVID-19, including the development of antiviral drugs and diagnostic tests. The distribution of ACE2 on the surface of host cells may play a key role in exploring the pathogenesis of SARS-COV-2. Acute and chronic cardiovascular diseases may be associated with the clinical severity of COVID-19.
Researchers have reported some useful information about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leading to CoV disease 2019 (COVID-19). Several studies have been performed in order to develop antiviral drugs, from which a few have been prescribed to patients. Also, several diagnostic tests have been designed to accelerate the process of identifying and treating COVID-19. It has been well-documented that the surface of host cells is covered by some receptors, known as angiotensin-converting enzyme 2 (ACE2), which mediates the binding and entry of CoV. After entering, the viral RNA interrupts the cell proliferation system to activate self-proliferation. However, having all the information about the outbreakof the SARS-COV-2, it is not still clear which factors determine the severity of lung and heart function impairment induced by COVID-19. A major step in exploring SARS-COV-2 pathogenesis is to determine the distribution of ACE2 in different tissues . In this review, the structure and origin of CoV, the role of ACE2 as a receptor of SARS-COV-2 on the surface of host cells, and the ACE2 distribution in different tissues with a focus on lung and cardiovascular system have been discussed. It was also revealed that acute and chronic cardiovascular diseases (CVDs) may result in the clinical severity of COVID-19. In conclusion, this review may provide useful information in developing some promising strategies to end up with a worldwide COVID-19 pandemic. Communicated by Ramaswamy H. Sarma
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