期刊
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
卷 39, 期 9, 页码 3186-3193出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2020.1761880
关键词
Spinel ferrites nanoparticles; electrospinning technique; XRD; TEM; anti-cancer agent; anti-bacterial agent
资金
- Deanship of Scientific Research (DSR)
- Institute for Research & Medical Consultations (IRMC) of Imam Abdulrahman Bin Faisal University [2018-004-IRMC]
In this study, Cd-substituted Ni-Co ferrite nanofibers were synthesized using electrospinning technique, with a low concentration of Nd as a dopant. The nanofibers showed inhibitory effects on both cancerous cells and bacterial strains, demonstrating anti-cancer and anti-bacterial activities. This study provides a novel method for the synthesis of nanofibers with potential biomedical applications.
Here we report the electrospinning synthesis of Cd-substituted Ni-Co ferrite Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x <= 0.25) nanofiber (NFs) with a very low concentration of Nd as a dopant. The structure and surface morphology of the Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x <= 0.25) NFs were analyzed by X-ray powder pattern (XRD), transmission and scanning electron microscopes (TEM) along with Energy-dispersive X-ray (EDX). We have examined the biological applications of the Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x <= 0.25) NFs on both cancerous cells and bacterial cells. We have found that Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x <= 0.25) NFs produced inhibitory action on the human colorectal carcinoma cells (HEK-293) and also showed inhibitory action on the bacterial strains (S. aureus and E. coli) respectively. Finally, this is the first report on the synthesis of Cd- substituted Co-Ni ferrite nanofibers using electrospinning technique exhibiting anti-cancer and anti-bacterial activities. Communicated by Ramaswamy H. Sarma
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