期刊
CHEMBIOCHEM
卷 17, 期 17, 页码 1585-1588出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600261
关键词
anti-malaria; biosynthesis; jogyamycin; natural products; pactamycin; Streptomyces
资金
- OSU College of Pharmacy
Pactamycin is a bacteria-derived aminocyclitol antibiotic with a wide-range of biological activity. Its chemical structure and potent biological activities have made it an interesting lead compound for drug discovery and development. Despite its unusual chemical structure, many aspects of its formation in nature remain elusive. Using a combination of genetic inactivation and metabolic analysis, we investigated the tailoring processes of pactamycin biosynthesis in Streptomyces pactum. The results provide insights into the sequence of events during the tailoring steps of pactamycin biosynthesis and explain the unusual production of various pactamycin analogues by S.pactum mutants. We also identified two new pactamycin analogues that have better selectivity indexes than pactamycin against malarial parasites.
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