期刊
CHEMBIOCHEM
卷 17, 期 16, 页码 1513-1517出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600078
关键词
antibiotics; intracellular pathogen; itaconate degradation; medicinal chemistry; pantothenate
资金
- Canadian Institute of Health Research (CIHR)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
In the context of increasing global antibiotic resistance, the need for alternative therapeutic targets is great. Although new antibiotics and resistance inhibitors provide temporary solutions, they are bound to become obsolete. In this work, we propose a new approach, coined bacterio-modulation that aims to restore macrophage potency towards bacterial strains that are able to survive in phagolysosomes. One key defense in the macrophage's arsenal is itaconate, an endogenous molecule with antimicrobial activity. Some intracellular pathogens have evolved to produce itaconate-degrading enzymes, which are required for intracellular proliferation and to promote pathogenicity. We herein present the first molecule able to resensitize Salmonella enterica to itaconate.
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