期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 13, 页码 3963-3975出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c00196
关键词
lycopene; colitis; gut barrier; neuroinflammation; gut microbiome
资金
- Natural Science Foundation of China [81803231]
- Key Research and Development Plan of Shaanxi, China [2018NY-100]
- Shaanxi science and technology innovation team [2019TD-006]
- China postdoctoral science foundation [2019M653768, 2018T1104]
- Tang Cornell-China Scholars Program
Gut microbes play significant roles in colitis development. The current study was aimed to uncover the preventive effects of lycopene (LYC), a functional carotenoid component, on colitis and the accompanied behavior disorders. The current study demonstrated that LYC treatment (50 mg/kg body weight/day) for 40 days prevented the dextran sulfate sodium (DSS)-induced gut barrier damages and inflammatory responses in male mice. LYC improved DSS-induced depression and anxiety-like behavioral disorders by suppressing neuroinflammation and prevented synaptic ultrastructure damages by upregulating the expressions of neurotrophic factor and postsynaptic-density protein. Moreover, LYC reshaped the gut microbiome in colitis mice by decreasing the relative abundance of proteobacteria and increasing the relative abundance of Bifidobacterium and Lactobacillus. LYC also elevated the generation of short-chain fatty acids and inhibited the permeability of lipopolysaccharide in colitis mice. In conclusion, LYC ameliorate DSS-induced colitis and behavioral disorders via mediating microbes-gut-brain axis balance.
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