期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 16, 页码 4559-4565出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c00888
关键词
insect chitinase; physiological role; molting; structure; inhibitor; pesticide
资金
- National Natural Science Foundation of China [31830076, 31901916]
- China Postdoctoral Science Foundation [2019M650921]
Chitinase (EC 3.2.1.14) is an enzyme to breakdown beta-1,4-glycosidic bonds in chitin and chitooligosaccharides. The loss of chitinase enzymatic activity in insects results in severe exoskeleton defects and lethality at all developmental stages, indicating that insect chitinases can be promising pesticide targets. However, there are no pesticides known to target chitinases. This perspective will focus on the latest research progress of insect chitinases, paying special attention to crystal structures and chemical biology advances in the field. The physiological importance and unique structural features of insect chitinases may ensure the development of new pesticides through a novel acting mode.
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