期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 46, 页码 12893-12903出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c00641
关键词
manganese; trace metal; nutrients; essential element; neurotoxicity
资金
- National Institutes of Health [NIEHS R01ES010563, NIEHS R01ES020852]
Manganese (Mn) is an essential element that participates in several biological processes. Mn serves as a cofactor for several enzymes, such as glutamine synthetase and oxidoreductases, that have an important role in the defense of the organisms against oxidative stress. The diet is the main source of Mn intake for humans, and adequate daily intake levels for this metal change with age. Moreover, in higher amounts, Mn may be toxic, mainly to the brain. Here, we provide an overview of Mn occurrence in food, addressing its bioaccessibility and discussing the dietary standard and recommended intake of Mn consumption. In addition, we review some mechanisms underlying Mn-induced neurotoxicity.
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