期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 581, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119269
关键词
Liposome; Cancer Therapy; Preparation; Pharmacokinetics; Functionalization and Targeting; Cell Signaling Pathways and Gene Delivery
资金
- Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Science
Evaluation of axial properties including preparation, surface functionalization, and pharmacokinetics for delivery of pharmacologically active molecules and genes lead to pharmaceutical development of liposome in cancer therapy. Here, analysis of effects of the axial properties of liposome based on cancer treatment modalities as individually and coherently is vital and shows deserving further investigation for the future. In this review, recent progress in the analysis of preparation approaches, optimizing pharmacokinetic parameters, functionalization and targeting improvement and modulation of biological factors and components resulting in a better function of liposome in cancer for drug/gene delivery and immunotherapy are discussed. Here, recent developments on liposome with vaccines and immunoadjuvant carriers, and antigen-carrier system to cancer immunotherapy are introduced.
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