期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 15, 期 -, 页码 2563-2582出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S243223
关键词
glioma; brain barrier; nanoparticle drug delivery system; efficacy improvement strategies; deficiencies of NDDS
资金
- Zhejiang Provincial Natural Science Foundation of China [LY18H180009]
- National Natural Science Foundation of China [61801160, 81730108]
- Key Project of Zhejiang Project Ministry of Science and Technology [2015C03055]
- Key Project of Hangzhou Ministry of Science and Technology [20162013A07]
Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including bloodbrain barrier (BBB), blood-brain tumor barriers (BBTB), brain-cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed.
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